Anti-SLAMF7 Recombinant Antibody (Elotuzumab)
CAT#: TAB-743
Recombinant humanized antibody expressed in CHO binding to human SLAMF7/CD319. Elotuzumab is a humanized monoclonal antibody which is under phase III clinical investigation in relapsed multiple myeloma.
Tested Data
Gene Expression
ELISA
Figure 1 Anti-SLAMF7 Recombinant Antibody (TAB-743) in ELISA
ELISA analysis of TAB-743 was performed by coating with SLAMF7 antigen. The HRP-conjugated goat anti-human IgG was used as a secondary antibody.
WB
Figure 2 Anti-SLAMF7 Recombinant Antibody (TAB-743) in WB
Western blot analysis of TAB-743 was performed with 3 µg onto a 12% Tris-HCl polyacrylamide gel in β-mercaptoethanol-reduced (Lane 1) conditions. Goat Anti-Human IgG HRP secondary antibody at a dilution of 1:8,000 for 75 minutes.
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Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/61654/1269_D5_1_selected.jpg
Normal Tissue
Figure 2 Testis
Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_6_6.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55945/134333_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (U-266/70)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000026751-SLAMF7
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1 - kappa
- Species Reactivity
- Human
- Applications
- Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, IHC and most other immunological methods.
- CAS
- 915296-00-3
- Generic Name
- elotuzumab
- UNII
- 1351PE5UGS
- MW
- 145.5 kDa
- Related Disease
- Multiple myeloma (MM)
Product Property
- Purity
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- elotuzumab;915296-00-3;HuLuc63;PDL063;PDL-063;BMS-901608;HuLuc63;SLAMF7;SLAM family member 7;19A;CD319;CRACC;CS1;protein 19A;CD2 subset 1;19A24 protein;membrane protein FOAP-12;CD2-like receptor activating cytotoxic cells;CD2-like receptor-activating cyto
- Gene ID
- 57823
- UniProt ID
- Q9NQ25
REVIEWS AND Q&AS
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Robust Performance in Myeloma Research
Using Elotuzumab in our research has greatly enhanced our understanding of immune mechanisms in multiple myeloma. Its precise targeting of SLAMF7/CD319 has been invaluable in advancing our therapeutic approaches.
Versatile and Effective
This antibody has shown remarkable versatility across different assays, from ELISA to flow cytometry, consistently delivering high-quality data that underpins our cancer research projects.
Reliable in Experimental Applications
The antibody's reliability has been proven time and again in immunoprecipitation and functional assays, reinforcing its role as a reliable tool in our immunological research.
Q&As
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What key applications does this antibody support?
A: The antibody is suitable for a wide range of applications, including functional studies, immunofluorescence, neutralization assays, ELISA, flow cytometry, immunoprecipitation, and immunohistochemistry, making it highly versatile for scientific research.
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What is Anti-SLAMF7 (Elotuzumab) used for?
A: Elotuzumab is a humanized monoclonal antibody targeting SLAMF7/CD319, under investigation for treating relapsed multiple myeloma, providing a potent tool in both clinical and research applications.
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In what diseases can Elotuzumab be considered as a therapeutic option?
A: Primarily investigated in multiple myeloma, Elotuzumab leverages its action on SLAMF7 to potentially extend its application to other diseases where modulation of immune responses can be beneficial.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-743, RRID: AB_3111998)
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Biosimilar Overview
Please refer to Elotuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Elotuzumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Elotuzumab"
Afuco™ Anti-SLAMF7 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-743)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human SLAMF7/CD319. It is a humanized monoclonal antibody which is under phase III clinical investigation in relapsed multiple myeloma.
DrugMonitor™ Anti-Elotuzumab Antibody (VS-1224-YC413)Elotuzumab is a humanized IgG1 monoclonal antibody indicated for use with lenalidomide and dexamethasone in multiple myeloma treatment. The DrugMonitor™ Anti-Elotuzumab Antibody (VS-1224-YC413) is an anti-drug antibody (ADA) against Elotuzumab. This drug-based antibody is raised in mice immunized with the Elotuzumab. The anti-Elotuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Elotuzumab in samples.
See other products for "SLAMF7"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-570CL | Human Anti-SLAMF7 Recombinant Antibody (TAB-570CL) | IF, IHC, Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1547MZ | Recombinant Mouse Anti-Human SLAMF7 Antibody (clone 273), PE-Conjugated | FC | Mouse antibody |
| HPAB-AP796-YC | Mouse Anti-SLAMF7 Recombinant Antibody (HPAB-AP796-YC) | ELISA, FC, IHC, Inhib | Mouse IgG1 |
| HPAB-AP797-YC | Mouse Anti-SLAMF7 Recombinant Antibody (HPAB-AP797-YC) | ELISA, FC, IHC, Inhib | Mouse IgG2a |
| HPAB-AP798-YC | Mouse Anti-SLAMF7 Recombinant Antibody (HPAB-AP798-YC) | ELISA, FC, IHC, Inhib | Mouse IgG2b |
| HPAB-AP799-YC | Human Anti-SLAMF7 Recombinant Antibody (HPAB-AP799-YC) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4058 | Hi-Affi™ Recombinant Rabbit Anti-SLAMF7 Monoclonal Antibody (SI125DS) | ELISA | IgG |
| MOR-4430 | Hi-Affi™ Recombinant Rabbit Anti-SLAMF7 Monoclonal Antibody (SI523DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-743 | Afuco™ Anti-SLAMF7 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-743) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP796-YC-S(P) | Mouse Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP796-YC-S(P)) | ELISA, FC, IHC, Inhib | Mouse scFv |
| HPAB-AP797-YC-S(P) | Mouse Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP797-YC-S(P)) | ELISA, FC, IHC, Inhib | Mouse scFv |
| HPAB-AP798-YC-S(P) | Mouse Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP798-YC-S(P)) | ELISA, FC, IHC, Inhib | Mouse scFv |
| HPAB-AP799-YC-S(P) | Human Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP799-YC-S(P)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Human scFv |
| HPAB-AP800-YC-S(P) | Human Anti-SLAMF7 Recombinant Antibody; scFv Fragment (HPAB-AP800-YC-S(P)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP796-YC-F(E) | Mouse Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP796-YC-F(E)) | ELISA, FC, IHC, Inhib | Mouse Fab |
| HPAB-AP797-YC-F(E) | Mouse Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP797-YC-F(E)) | ELISA, FC, IHC, Inhib | Mouse Fab |
| HPAB-AP798-YC-F(E) | Mouse Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP798-YC-F(E)) | ELISA, FC, IHC, Inhib | Mouse Fab |
| HPAB-AP799-YC-F(E) | Human Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP799-YC-F(E)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Humanized Fab |
| HPAB-AP800-YC-F(E) | Human Anti-SLAMF7 Recombinant Antibody; Fab Fragment (HPAB-AP800-YC-F(E)) | ELISA, FC, IHC, Inhib, ADCC, FuncS | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY237 | AbPlus™ Anti-SLAMF7 Magnetic Beads (DM10) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY199 | CytoStream™ Mouse Anti-SLAMF7 Recombinant Antibody (VS-0225-XY199) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY183 | Human Anti-SLAMF7 (clone Elotuzumab) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC83 | Recombinant Anti-SLAMF7 Vesicular Antibody, EV Displayed (VS-0425-YC83) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6620 | Anti-SLAMF7 Immunohistochemistry Kit | IHC |
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